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Several drugs are currently in advanced clinical trials: Phase III Clinical Trials: IBI362 (Innovent/Eli Lilly), CagriSema (Novo Nordisk), Retatrutide (Eli Lilly), and Survodutide (Boehringer Ingelheim)

Semaglutide is a prescription medication originally developed for type 2 diabetes but also approved in certain forms for weight management

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The enzyme transamidinase (AGAT) catalyzes the transfer of an amidino group from arginine to the N-terminal amine of glycine to yield ornithine and guanidinoacetate (GAA)